Omega-3 Fatty Acids Reduce Side Effects of Cancer Drug in Mice
Author Information
Author(s): Hardman W E, Moyer M P, Cameron I L
Primary Institution: Pennington Biomedical Research Center, Louisiana State University
Hypothesis
Can the omega-3 fatty acid product INCELL AAFA™ reduce the side effects of CPT-11 chemotherapy in mice?
Conclusion
The study found that a diet including 2% AAFA™ significantly reduced the side effects of CPT-11 treatment in mice.
Supporting Evidence
- 2% AAFA™ in the diet decreased apoptotic figures in the duodenal crypts.
- Consumption of AAFA™ improved white blood cell counts.
- 2% AAFA™ significantly decreased liver PGE2 levels.
Takeaway
Feeding mice a special omega-3 product helped them feel better and have fewer side effects from a cancer drug.
Methodology
Mice were divided into groups and fed diets with varying amounts of AAFA™ before receiving CPT-11 chemotherapy, followed by analysis of blood and tissue samples.
Potential Biases
Potential bias due to funding from the manufacturer of the omega-3 product.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Forty male Swiss mice, 6 weeks old.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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