Spread of E. coli Strains with CTX-M-15
Author Information
Author(s): Coque Teresa M., Novais Ângela, Carattoli Alessandra, Poirel Laurent, Pitout Johann, Peixe Luísa, Baquero Fernando, Cantón Rafael, Nordmann Patrice
Primary Institution: Hospital Universitario Ramón y Cajal, Madrid, Spain
Hypothesis
What factors contribute to the worldwide spread of CTX-M-15 producing E. coli strains?
Conclusion
The study found that the global dissemination of CTX-M-15 is primarily driven by specific E. coli clones and their associated plasmids.
Supporting Evidence
- Most isolates belonged to phylogroups B2 (50%) and D (25%).
- An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries.
- CTX-M-15 plasmids corresponded to IncFII group with overrepresentation of 3 plasmid DNA profiles.
Takeaway
Some types of E. coli can spread a special gene that makes them resistant to many medicines, and this is happening all over the world.
Methodology
The study analyzed 43 E. coli isolates and 6 plasmids from various countries, assessing their genetic elements and resistance patterns.
Limitations
The study may not cover all geographic areas or all variants of CTX-M enzymes.
Participant Demographics
Isolates were from hospitalized patients in Canada, India, Kuwait, France, Switzerland, Portugal, and Spain.
Digital Object Identifier (DOI)
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