Connective tissue growth factor promoter activity in normal and wounded skin
2008
Connective Tissue Growth Factor in Skin Repair
Sample size: 4
publication
Evidence: moderate
Author Information
Author(s): Kapoor Mohit, Liu Shangxi, Huh Kun, Parapuram Sunil, Kennedy Laura, Leask Andrew
Primary Institution: University of Western Ontario
Hypothesis
What are the exact cell types that express CTGF in normal and wounded skin?
Conclusion
CTGF expression in skin correlates with myofibroblast induction, and CTGF-expressing pericytes significantly contribute to myofibroblast activity during tissue repair.
Supporting Evidence
- CTGF expression was absent in unwounded skin but induced post-wounding.
- Approximately 30% of myofibroblasts in the wound were derived from pericytes.
- CTGF promoter activity was detected in myofibroblasts and pericytes during tissue repair.
Takeaway
This study found that a special protein called CTGF helps skin heal by working with certain cells called myofibroblasts and pericytes.
Methodology
Transgenic knock-in mice were used to study CTGF promoter activity in skin before and after wounding.
Participant Demographics
Mice aged 6 weeks were used in the study.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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