Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice
Author Information
Author(s): Tomomi Shimizu, Youhei Takeshita, Yasushi Takamori, Hisahiro Kai, Rie Sawamura, Hiroki Yoshida, Wataru Watanabe, Atsuko Tsutsumi, Yong Kun Park, Ken Yasukawa, Koji Matsuno, Kimiyasu Shiraki, Masahiko Kurokawa
Primary Institution: Kyushu University of Health and Welfare
Hypothesis
The study investigates the anti-HSV-1 efficacy of different ethanol extracts of Brazilian propolis in a murine model.
Conclusion
Brazilian propolis extracts moderately limited the development of herpetic skin lesions in mice infected with HSV-1.
Supporting Evidence
- AF-07 and 08 significantly reduced virus titers in brain and/or skin on day 4.
- AF-06 and 08 significantly enhanced delayed-type hypersensitivity to inactivated HSV-1 antigen.
- Oral AF-08 administration significantly augmented interferon production by splenocytes.
Takeaway
Brazilian propolis can help reduce skin problems caused by a virus in mice, showing it might be useful for treating infections.
Methodology
Ethanol extracts of Brazilian propolis were administered orally to HSV-1-infected mice to evaluate their efficacy against the infection.
Limitations
The study was conducted in mice, and results may not directly translate to humans.
Participant Demographics
BALB/c female mice, 6 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website