Analyzing Promoter Regions of Co-Expressed Genes
Author Information
Author(s): Veerla Srinivas, Höglund Mattias
Primary Institution: Lund University Hospital
Hypothesis
Co-regulated genes would show similar or overlapping patterns of binding site motifs.
Conclusion
Promoter clustering based on global promoter features greatly improves the identification of shared transcription factor binding sites in co-expressed genes.
Supporting Evidence
- Promoter clustering enhances the identification of common transcription factor binding sites.
- 15% of analyzed promoter regions contained transcription factor start sites for additional genes transcribed in the opposite direction.
Takeaway
The study looked at how genes that work together have similar starting points, helping scientists understand how they are controlled.
Methodology
The study used microarray data to identify co-expressed genes and analyzed their promoter sequences for transcription factor binding sites.
Limitations
The presence of transcription start sites for additional genes in analyzed promoter regions complicates the analysis.
Statistical Information
P-Value
0.0005
Statistical Significance
p = 0.0005
Digital Object Identifier (DOI)
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