Prevalence of Amyloid Deposition in Rheumatoid Arthritis Patients in Iran
Author Information
Author(s): Alishiri G Hussein, Salimzadeh Ahmad, Owlia Mohammad Bagher, Forghanizadeh Jafar, Setarehshenas Roya, Shayanfar Nasrin
Primary Institution: Baqyatollah University of Medical Sciences, Tehran, Iran
Hypothesis
What is the prevalence of secondary amyloidosis in Iranian patients with rheumatoid arthritis?
Conclusion
The prevalence of fat amyloid deposits in Iranian patients with rheumatoid arthritis is low, with many cases being subclinical.
Supporting Evidence
- Amyloid deposition was found in 15 out of 220 patients, which is 6.8%.
- Thirteen patients had minimal amyloid deposits, and two had moderate deposits.
- Nine out of the 15 cases with amyloid deposition presented with clinical amyloidosis.
Takeaway
The study found that only a small number of Iranian patients with rheumatoid arthritis had amyloid deposits, and many of them didn't show any symptoms.
Methodology
The study involved 220 patients with rheumatoid arthritis who underwent abdominal subcutaneous fat biopsy to check for amyloid deposits.
Limitations
The small number of positive cases limits the ability to draw definitive conclusions.
Participant Demographics
167 female and 53 male patients with a minimum five-year history of rheumatoid arthritis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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