Cell cycle perturbations and apoptosis induced by isohomohalichondrin B (IHB), a natural marine compound
1999
Effects of Isohomohalichondrin B on Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Bergamaschi D, Ronzoni S, Taverna S, Faretta M, Feudis P De, Faircloth G, Jimeno J, Erba E, D'Incalci M
Primary Institution: Istituto di Ricerche Farmacologiche ‘Mario Negri’
Hypothesis
Isohomohalichondrin B (IHB) induces cell cycle perturbations and apoptosis in human cancer cell lines.
Conclusion
IHB is a novel potent anti-tumour drug that causes delayed S-phase progression, mitotic block, tetraploidy, and apoptosis in cancer cell lines.
Supporting Evidence
- IHB exposure caused a delayed progression through S-phase.
- There was a dramatic block in G2M phase of the cell cycle.
- Tetraploid cell populations appeared in several cancer cell lines.
- Apoptotic death was detected in leukaemic cells when blocked in mitotic prophase.
Takeaway
A natural compound called Isohomohalichondrin B can stop cancer cells from dividing and can make them die.
Methodology
The study used flow cytometric and biochemical techniques to analyze the effects of IHB on selected human cancer cell lines.
Digital Object Identifier (DOI)
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