The Origin of Secretin Receptor and Its Relationship with Orexin
Author Information
Author(s): Tam Janice K. V., Lau Kwan-Wa, Lee Leo T. O., Chu Jessica Y. S., Ng Kwong-Man, Fournier Alain, Vaudry Hubert, Chow Billy K. C.
Primary Institution: The University of Hong Kong
Hypothesis
Secretin and orexin receptors could have been functional complementary partners in mediating physiological processes before the origin of mammals.
Conclusion
The study provides evidence that secretin and orexin could modulate physiological processes in coordination before the divergence of mammals.
Supporting Evidence
- Secretin and orexin were shown to activate their mutual receptors in frogs.
- Functional studies indicated that secretin receptors were already present in lobe-finned fish.
- The study suggests that secretin and orexin evolved independently but may have shared similar functions.
Takeaway
This study looks at how two important hormones, secretin and orexin, might have worked together in early animals, even before mammals existed.
Methodology
The study involved cloning and functional characterization of secretin receptors from lungfish and frogs, and testing their activation by secretin and orexin.
Limitations
The study could not identify a secretin-like sequence in lungfish, which may limit the understanding of secretin's evolutionary history.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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