Induction of matrix metalloproteinase-1 (MMP-1) during epidermal invasion of the stroma in human skin organ culture: keratinocyte stimulation of fibroblast MMP-1 production
2001
How skin cells invade deeper layers with growth factors
publication
Author Information
Author(s): Moon S E, Dame M K, Remick D R, Elder J T, Varani J
Primary Institution: The University of Michigan Medical School
Hypothesis
Does epidermal growth factor (EGF) influence the production of matrix metalloproteinase-1 (MMP-1) during skin cell invasion?
Conclusion
The study found that EGF treatment leads to skin cell invasion and increased MMP-1 production, but certain antagonists can inhibit these effects.
Supporting Evidence
- EGF treatment caused skin cells to invade the stroma.
- MMP-1 production was stimulated by keratinocytes in the presence of EGF.
- Blocking EGF receptors reversed abnormal histological features.
Takeaway
When skin cells are given a special growth factor, they can grow and invade deeper layers, but blocking this factor can stop some of that growth.
Methodology
Human skin organ cultures were incubated with or without epidermal growth factor (EGF) to observe effects on cell invasion and MMP production.
Digital Object Identifier (DOI)
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