Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects
1999
Fish Oil Helps Cancer Treatment
publication
Author Information
Author(s): Hardman W E, Moyer M P, Cameron I L
Primary Institution: The University of Texas Health Science Center at San Antonio
Hypothesis
Does fish oil supplementation enhance the efficacy of CPT-11 against breast cancer while reducing intestinal side effects?
Conclusion
Fish oil supplements may improve the effectiveness of CPT-11 treatment for breast cancer and reduce intestinal damage.
Supporting Evidence
- CPT-11 halted the growth of MCF7 xenografts in mice fed a corn oil diet.
- Fish oil supplementation led to significant regression of MCF7 xenografts.
- Intestinal mucosal architecture was largely unchanged in mice fed fish oil compared to those not receiving CPT-11.
Takeaway
Adding fish oil to the diet can help cancer treatment work better and make it less harmful to the stomach.
Methodology
Mice with MCF7 breast cancer were treated with CPT-11 and fed diets with different levels of fish oil to assess tumor growth and intestinal health.
Participant Demographics
Mice with MCF7 human breast carcinoma xenografts.
Digital Object Identifier (DOI)
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