GSTM1 Null Polymorphism and Primary Open Angle Glaucoma
Author Information
Author(s): Rocha Auta Viviane, Talbot Teddy, Magalhães da Silva Thiago, Almeida Maria Clarinda, Menezes Carlos Alberto, Di Pietro Giuliano, Rios-Santos Fabrício
Primary Institution: Universidade Estadual de Santa Cruz
Hypothesis
Is the GSTM1 null polymorphism a risk factor in Primary Open Angle Glaucoma?
Conclusion
The GSTM1 null polymorphism is associated with an increased risk of Primary Open Angle Glaucoma in the Brazilian population.
Supporting Evidence
- The GSTM1 null genotype frequency was significantly higher in POAG patients (49.4%) than in controls (31.8%).
- The GSTM1 null genotype had an increased risk of developing POAG (OR=2.01).
- The association between GSTM1 and POAG remained statistically significant when adjusted for confounding factors.
Takeaway
People with a specific gene variation (GSTM1 null) are more likely to develop a type of eye disease called glaucoma.
Methodology
A case-control study with 87 patients with POAG and 85 healthy controls, genotyping for GST polymorphisms using PCR.
Limitations
The study has a small sample size, which may limit the statistical power of the findings.
Participant Demographics
87 patients (27 men, 60 women; mean age 63.5) and 85 controls (29 men, 56 women; mean age 61.8) from southern Bahia, Brazil.
Statistical Information
P-Value
0.018
Confidence Interval
1.13–3.9
Statistical Significance
p<0.05
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