Nitric Oxide Antagonizes the Acid Tolerance Response that Protects Salmonella against Innate Gastric Defenses
2008
How Nitric Oxide Affects Salmonella's Ability to Survive in Acidic Environments
Sample size: 10
publication
10 minutes
Evidence: high
Author Information
Author(s): Bourret Travis J., Porwollik Steffen, McClelland Michael, Zhao Rui, Greco Todd, Ischiropoulos Harry, Vázquez-Torres Andrés
Primary Institution: University of Colorado Health Sciences Center
Hypothesis
Can reactive nitrogen species (RNS) alter the acid tolerance response (ATR) of Salmonella?
Conclusion
Nitric oxide and other reactive nitrogen species inhibit the acid tolerance response of Salmonella, reducing its virulence.
Supporting Evidence
- Salmonella exposed to nitric oxide donors showed reduced survival in acidic conditions.
- The study found that nitric oxide prevents Salmonella from mounting a protective acid tolerance response.
- Mice infected with adapted Salmonella shed more bacteria than those infected with non-adapted strains.
Takeaway
This study shows that certain chemicals in our stomach can make it harder for Salmonella bacteria to survive and cause sickness.
Methodology
The study involved testing Salmonella's survival in acidic conditions with and without nitric oxide donors.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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