Synthesis of Fluorous Calix[4]arenes
Author Information
Author(s): Osipov Maksim, Chu Qianli, Geib Steven J, Curran Dennis P, Weber Stephen G
Primary Institution: University of Pittsburgh
Hypothesis
Combining fluorous chemistry with calixarenes will create effective molecular recognition scaffolds.
Conclusion
The synthesized deep-cavity fluorous calix[4]arenes are soluble in several fluorous solvents and show potential as fluorescent sensors.
Supporting Evidence
- Fluorous calix[4]arenes were synthesized in cone conformation.
- These compounds showed solubility in various fluorous solvents.
- Functionalization of the calix[4]arene scaffold was explored to enhance its applications.
Takeaway
Scientists made special molecules called fluorous calix[4]arenes that can help detect other substances and work well in certain liquids.
Methodology
The study involved synthesizing fluorous calix[4]arenes through O-alkylation and testing their solubility in various solvents.
Limitations
The solubility of some synthesized compounds was not as expected, limiting their potential applications.
Digital Object Identifier (DOI)
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