Loss of heterozygosity at 18q21 and colorectal cancer prognosis
Author Information
Author(s): Jernvall P, Mäkinen M J, Karttunen T J, Mäkelä J, Vihko P
Primary Institution: University of Oulu
Hypothesis
Is loss of heterozygosity at 18q21 indicative of recurrence and poor prognosis in colorectal cancers?
Conclusion
Loss of heterozygosity at 18q21 is associated with a higher rate of recurrence and poorer survival in colorectal cancer patients.
Supporting Evidence
- Loss of heterozygosity at 18q21 was significantly associated with the development of recurrence.
- 82% of recurrences occurred in patients with Dukes' classes B and C.
Takeaway
If a patient has a specific change in their cancer genes, they might have a higher chance of their cancer coming back, which means doctors can help them better.
Methodology
The study analyzed primary colorectal cancer specimens for loss of heterozygosity using PCR and fragment analysis.
Participant Demographics
Patients with primary colorectal cancer, specifically those in Dukes' classes B and C.
Statistical Information
P-Value
0.01
Statistical Significance
p=0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website