Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives
2011
Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives
publication
Evidence: moderate
Author Information
Author(s): Moribe Kunikazu, Limwikrant Waree, Higashi Kenjirou, Yamamoto Keiji
Primary Institution: Graduate School of Pharmaceutical Sciences, Chiba University
Hypothesis
The study investigates the formulation of drug nanoparticles using ascorbic acid derivatives and their therapeutic applications.
Conclusion
Ascorbic acid derivatives can be effectively used in nanoparticle formulations for drug delivery and therapeutic applications.
Supporting Evidence
- Ascorbic acid derivatives can act as antioxidants and pharmaceutical excipients.
- Hydrophilic and hydrophobic ascorbic acid derivatives have been formulated into nanoparticles.
- Nanoparticle formulations can enhance drug solubility and stability.
- ASC-P has shown potential as a model drug for nanosized lipid carriers.
- ASC-P-encapsulated nanoparticles demonstrated improved stability and reduced cytotoxicity.
Takeaway
This study shows that special forms of vitamin C can help make tiny particles that carry medicine, making it easier for the body to use them.
Methodology
The study reviews various formulations of drug nanoparticles using ascorbic acid derivatives and their physicochemical properties.
Digital Object Identifier (DOI)
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