Fluorescence Imaging of Drug Transport in Prostate Tumors
Author Information
Author(s): Hamblin M R, Rajadhyaksha M, Momma T, Soukos N S, Hasan T
Primary Institution: Wellman Laboratories of Photomedicine, Harvard Medical School
Hypothesis
The molecular size and charge of polymeric drug conjugates affect their transport and extravasation in tumors.
Conclusion
Anionic polymeric drug conjugates lead to faster tissue fluorescence than cationic ones, and larger conjugates can produce tissue fluorescence faster than smaller ones.
Supporting Evidence
- Anionic conjugates produced tissue fluorescence faster than cationic ones.
- Larger molecular weight conjugates produced tissue fluorescence faster than smaller ones with the same charge.
Takeaway
This study looked at how different types of drug molecules move in prostate tumors, finding that some types work better than others.
Methodology
Fluorescence scanning laser microscopy was used to track the pharmacokinetics of polymeric drug conjugates in a rat prostate cancer model.
Participant Demographics
Rat model of prostate cancer.
Digital Object Identifier (DOI)
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