Loss of CAR in Gastric Cancer
Author Information
Author(s): Anders M, Vieth M, Röcken C, Ebert M, Pross M, Gretschel S, Schlag P M, Wiedenmann B, Kemmner W, Höcker M
Primary Institution: Charité Medical School
Hypothesis
Is the loss of the coxsackie and adenovirus receptor (CAR) involved in gastric cancer progression?
Conclusion
The study concludes that loss of CAR is associated with more severe disease states and reduced survival in gastric cancer.
Supporting Evidence
- Loss of CAR was found in 56% of gastric cancer specimens.
- Loss of CAR correlated with decreased differentiation and increased metastases.
- CAR negativity was associated with reduced carcinoma-specific survival.
Takeaway
This study found that when a specific protein called CAR is missing in stomach cancer, the cancer tends to be worse and patients may not live as long.
Methodology
The study analyzed CAR in 196 gastric adenocarcinomas and non-cancerous samples using immunohistochemistry and immunofluorescence.
Limitations
The study did not include patients who died of non-gastric cancer-related causes in survival analyses.
Participant Demographics
Patients aged 25 to 87 years, mean age 64.2 years.
Statistical Information
P-Value
p=0.025
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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