Peroxisome Proliferator-Activated Receptors in the Modulation of the Immune/Inflammatory Response in Atherosclerosis
2008
PPARs and Inflammation in Atherosclerosis
publication
Evidence: moderate
Author Information
Author(s): Ana Z. Fernandez
Primary Institution: Instituto Venezolano de Investigaciones Científicas (I.V.I.C.)
Hypothesis
How do peroxisome proliferator-activated receptors (PPARs) modulate the immune and inflammatory response in atherosclerosis?
Conclusion
PPAR activation may provide a therapeutic approach to reduce inflammation in atherosclerosis.
Supporting Evidence
- PPARs can reduce inflammatory markers in atherosclerosis.
- Activation of PPARs can inhibit the expression of pro-inflammatory adhesion molecules.
- PPAR-γ ligands can block the activation of NF-κB, a key player in inflammation.
Takeaway
PPARs are special proteins that help control inflammation in the body, and they might be used to help treat heart disease.
Methodology
The study reviews existing literature on PPARs and their effects on inflammation in atherosclerosis.
Limitations
The exact natural ligands for PPARs in vivo remain unclear.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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