Spoligotype Database of Mycobacterium tuberculosis
Author Information
Author(s): Christophe Sola, Ingrid Filliol, Maria Cristina Gutierrez, Igor Mokrousov, Veronique Vincent, Nalin Rastogi
Primary Institution: Institut Pasteur de Guadeloupe
Hypothesis
The study aims to analyze the biogeographic distribution of Mycobacterium tuberculosis spoligotypes and their epidemiological significance.
Conclusion
The updated database contains 3,319 spoligotype patterns and highlights the global distribution and specific shared types of M. tuberculosis.
Supporting Evidence
- The database includes 3,319 spoligotyping patterns from various origins.
- 259 shared types were identified, containing 2,779 isolates.
- Seven major genetic groups represented 37% of all clustered isolates.
- Two types were found almost exclusively in the USA, accounting for 9% of clustered isolates.
- Most shared types contained a low number of patient isolates and were geographically confined.
Takeaway
Researchers created a big list of different types of tuberculosis germs from around the world to see how they spread and where they come from.
Methodology
The study involved collecting and analyzing spoligotyping patterns from various sources and constructing a database for phylogenetic analysis.
Potential Biases
The study acknowledges the possibility of sampling bias in the distribution of spoligotypes.
Limitations
Potential sampling bias and representativeness of isolates from different regions may affect the results.
Participant Demographics
The database includes spoligotypes from 47 countries, with a significant number from Europe and the USA.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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