Modulation of RANTES expression by HCV core protein in liver derived cell lines
2007
How HCV Core Protein Affects RANTES Expression in Liver Cells
publication
Evidence: moderate
Author Information
Author(s): Ruggieri Anna, Franco Marina, Gatto Ilaria, Kumar Ajit, Rapicetta Maria
Primary Institution: Istituto Superiore di SanitÃ
Hypothesis
The study examines the effect of HCV core and structural proteins on RANTES expression in liver-derived cell lines.
Conclusion
HCV core protein has opposite effects on the expression of RANTES in different cell types in vitro.
Supporting Evidence
- HCV core protein inhibited RANTES expression in HepG2 cells.
- RANTES expression was induced in Chang Liver cells by HCV core protein.
- The study suggests that IRF-1 levels may mediate RANTES expression in liver cells.
Takeaway
The study found that the HCV core protein can either increase or decrease a protein called RANTES in liver cells, depending on the type of cell.
Methodology
The study used flow cytometry, quantitative RT-PCR, and luciferase assays to analyze RANTES expression in HepG2 and Chang Liver cell lines.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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