Diagnostic X-rays and Chronic Myeloid Leukaemia Risk
Author Information
Author(s): S. Preston-Martin, D.C. Thomas, M.C. Yu, B.E. Henderson
Primary Institution: University of Southern California School of Medicine
Hypothesis
Is chronic myeloid leukaemia (CML) related to exposure to diagnostic X-rays to the trunk during the 20 years before diagnosis?
Conclusion
The study found a significant association between diagnostic X-ray exposure and the risk of developing CML, particularly for exposures occurring 6-10 years before diagnosis.
Supporting Evidence
- Cases had more X-ray examinations of the spine, GI tract, and kidneys compared to controls.
- An odds ratio of 12.0 was found for back X-rays on five or more occasions.
- 17% of CML cases may be attributable to diagnostic X-ray exposure in the 6-10 years before diagnosis.
Takeaway
People who had a lot of X-rays on their back or stomach might be more likely to get a type of blood cancer called CML.
Methodology
The study involved interviews with 136 CML patients and 136 matched controls, focusing on their X-ray history over the 20 years prior to diagnosis.
Potential Biases
Interviewer bias and recall bias were potential concerns due to the nature of the case-control study.
Limitations
The study lacked a dosimetry component to validate reported radiography histories and may have been affected by recall bias.
Participant Demographics
Participants were Los Angeles County residents aged 20-69, with a majority being male and white.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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