Zhili Decoction Improves Ulcerative Colitis by Affecting Gut Microbiota and Inflammatory Pathways
Author Information
Author(s): Tan Tianying, Chen Qin, Chen Ping, Li Shuangshuang, Hu Wenting, Yang Tao, Jia Yingtian
Primary Institution: Guizhou University of Traditional Chinese Medicine
Hypothesis
The study investigates the effects of Zhili decoction on gut microbiota and related fecal metabolite levels in a mouse model of ulcerative colitis.
Conclusion
Zhili decoction alleviated ulcerative colitis by regulating gut flora, modulating related metabolite levels, and inhibiting the TLR4/NF-κB/NLRP3 pathway.
Supporting Evidence
- ZLD treatment significantly improved disease activity index scores in UC mice.
- Histopathological analysis showed reduced colonic inflammation in ZLD-treated groups.
- ZLD enhanced gut microbial diversity and altered the composition of gut microbiota.
- ZLD treatment increased levels of beneficial metabolites like butyrate acid.
Takeaway
Zhili decoction helps treat a gut problem called ulcerative colitis by changing the bacteria in the gut and reducing inflammation.
Methodology
The study used a mouse model of ulcerative colitis induced by dextran sulfate sodium, with treatment groups receiving different doses of Zhili decoction and assessments of gut microbiota and inflammatory markers.
Participant Demographics
Eight-week-old specific pathogen-free C57BL/6J mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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