The dual origin of the yeast mitochondrial proteome
Author Information
Author(s): Olof Karlberg, Bjo Ern Canba Eck, Charles G. Kurland, Siv G. E. Andersson
Primary Institution: Department of Molecular Evolution, Uppsala University
Hypothesis
The majority of genes encoding yeast mitochondrial proteins are descendants of two different genomic lineages that have evolved in different modes.
Conclusion
The study suggests that yeast mitochondrial proteins have diverse origins, with many being derived from both ancestral a-proteobacteria and the eukaryotic nuclear genome.
Supporting Evidence
- Half of the yeast mitochondrial proteins have no discernable bacterial homologues.
- One-tenth of the mitochondrial proteome can be traced to a-proteobacteria.
- Phylogenetic reconstructions show coherent clusters of purely eukaryotic homologues.
Takeaway
This study looks at where yeast get their mitochondrial proteins from, finding that some come from bacteria and others come from the yeast's own genes.
Methodology
Phylogenetic reconstructions were performed based on a set of more than 400 mitochondrial proteins in Saccharomyces cerevisiae.
Limitations
The study may underestimate the number of bacterial and eukaryotic homologues due to the stringent BLAST cut-off value used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website