Reply: Breast cancer, human papilloma virus and sexual activities
2008
HPV and Breast Cancer: A Possible Link
publication
Evidence: moderate
Author Information
Author(s): Lawson J S, Glenn W K, Whitaker N J
Primary Institution: School of Biotechnology and Biomolecular Sciences, University of New South Wales
Hypothesis
High-risk HPVs may be transmitted to the breast during sexual activities.
Conclusion
There is substantial but inconclusive evidence that high-risk HPVs may have a causal role in some breast cancers.
Supporting Evidence
- Three studies report that women with HPV-positive breast cancer are significantly younger than those with HPV-negative breast cancer.
- HPV DNA has been found in breast tumors in 11 out of 13 studies.
- Similar high-risk HPVs have been identified in breast tumors and cervical cancer in the same women.
Takeaway
Some scientists think that a virus called HPV might cause breast cancer in younger women, especially those who are sexually active.
Methodology
The presence of high-risk HPV DNA in breast tumours was analyzed mainly by PCR in various studies.
Limitations
The evidence is substantial but far from conclusive, indicating that more research is needed.
Statistical Information
P-Value
0.001, 0.049, 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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