Intensive Chemotherapy for Breast Cancer
Author Information
Author(s): Bos A M E, Graaf H de, Vries E G E de, Piersma H, Willemse P H B
Primary Institution: University Hospital, Groningen, The Netherlands
Hypothesis
The study aimed to evaluate the feasibility of an intensified CMF regimen with granulocyte colony-stimulating factor in premenopausal patients with node-positive breast cancer.
Conclusion
The intensified CMF regimen was feasible for most patients, allowing for high dose intensity despite increased toxicity.
Supporting Evidence
- 91% of patients received the projected total dose.
- All patients reached at least 111% of the projected dose intensity.
- 57% of patients were treated for infection during the study.
Takeaway
Doctors tested a stronger treatment for breast cancer and found that most patients could handle it, even though it made some feel sick.
Methodology
Twenty-three premenopausal breast cancer patients received 6 cycles of adjuvant CMF intravenously with granulocyte colony-stimulating factor.
Limitations
The study had a small sample size and reported significant toxicity.
Participant Demographics
All participants were premenopausal women with node-positive breast cancer.
Digital Object Identifier (DOI)
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