Effects of Fluoxetine on Weight and Metabolism in Type 2 Diabetes
Author Information
Author(s): Ye Zi, Chen Lili, Yang Zhen, Li Qin, Huang Ying, He Min, Zhang Shuo, Zhang Zhaoyun, Wang Xuanchun, Zhao Weiwei, Hu Ji, Liu Chao, Qu Shen, Hu Renming
Primary Institution: Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Hypothesis
This meta-analysis aims to assess the metabolic effects of fluoxetine in individuals with type 2 diabetes mellitus (T2DM).
Conclusion
Fluoxetine therapy can lead to weight loss and reductions in fasting plasma glucose, HbA1c, and triglycerides in individuals with T2DM.
Supporting Evidence
- Fluoxetine therapy resulted in an average weight loss of 4.27 kg compared to placebo.
- Fasting plasma glucose decreased by 1.41 mmol/L with fluoxetine treatment.
- Triglyceride levels were reduced by 0.54 mmol/L in patients receiving fluoxetine.
- HbA1c levels showed a decrement of 0.78% with fluoxetine, although not statistically significant.
- The studies included were all randomized, placebo-controlled trials.
Takeaway
Fluoxetine can help people with type 2 diabetes lose weight and improve their blood sugar levels.
Methodology
A systematic review and meta-analysis of five randomized, placebo-controlled trials assessing the effects of fluoxetine on weight and metabolic parameters in T2DM patients.
Potential Biases
Potential selection bias due to the exclusion of non-compliant participants and lack of detailed reporting on randomization and allocation concealment.
Limitations
The studies included varied in follow-up duration and participant demographics, and some studies had unclear randomization methods.
Participant Demographics
Participants were generally middle-aged individuals with type 2 diabetes, with a mix of genders.
Statistical Information
P-Value
p<0.00001
Confidence Interval
95%CI 2.58–5.97
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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