Targeting lymphangiogenesis to prevent tumour metastasis
Author Information
Author(s): Achen M G, Mann G B, Stacker S A
Primary Institution: Ludwig Institute for Cancer Research
Hypothesis
The growth of lymphatic vessels in or nearby tumours is associated with the metastatic spread of cancer.
Conclusion
The VEGF-C/VEGF-D/VEGFR-3 signalling system is a key regulator of tumour lymphangiogenesis and may be targeted to restrict cancer metastasis.
Supporting Evidence
- Recent studies suggest that lymphangiogenesis is linked to cancer metastasis.
- VEGF-C and VEGF-D are key proteins that promote lymphatic vessel growth.
- Blocking the VEGF-C/VEGF-D/VEGFR-3 pathway may help prevent cancer spread.
Takeaway
This study suggests that blocking certain proteins involved in the growth of lymphatic vessels could help stop cancer from spreading.
Methodology
The review discusses evidence from animal models and clinicopathological studies regarding lymphangiogenesis and cancer metastasis.
Limitations
The evidence for some growth factors in lymphangiogenesis is limited to a few animal models and requires broader analysis.
Digital Object Identifier (DOI)
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