Genetic Variants in Lipid Metabolism and Metabolic Syndrome
Author Information
Author(s): Cécile M Povel, Jolanda MA Boer, Sandra Imholz, Martijn ET Dollé, Edith JM Feskens
Primary Institution: National Institute for Public Health and the Environment (RIVM)
Hypothesis
Are single nucleotide polymorphisms (SNPs) related to multiple features of the metabolic syndrome?
Conclusion
Two SNPs associated with lipid metabolism were linked to low HDL-cholesterol levels and abdominal obesity, suggesting a genetic basis for their co-occurrence.
Supporting Evidence
- Two SNPs were significantly associated with low HDL-cholesterol and abdominal obesity.
- The association between these SNPs and metabolic syndrome features was partly independent.
- Findings suggest a genetic link between lipid metabolism and obesity.
Takeaway
Some genes can affect both cholesterol levels and body fat, which helps explain why people with low cholesterol often have belly fat.
Methodology
The study measured 373 SNPs in 3575 subjects and analyzed associations with metabolic syndrome features using log-linear models.
Limitations
Blood samples were taken from non-fasting subjects, which may have affected glucose measurements.
Participant Demographics
Participants were aged 20-59, from a rural area in the Netherlands.
Statistical Information
P-Value
<0.0001
Confidence Interval
95% CI 0.69; 0.86
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website