Gut Microbiota's Role in Dietary Quality and Cancer-Related Fatigue in Breast Cancer Patients
Author Information
Author(s): He Jianyun, Cheng Lan, Cheng Xinxin, Wang Yuting, Lin Xiaoxia, Xia Shufang
Primary Institution: Wuxi School of Medicine, Jiangnan University
Hypothesis
This study investigates the relationship between dietary quality and cancer-related fatigue (CRF) in breast cancer patients, focusing on the mediating role of gut microbiota.
Conclusion
Breast cancer patients with cancer-related fatigue may have inadequate nutrient intake and low dietary quality, which could be linked to gut microbiota-dependent pathways.
Supporting Evidence
- 43.6% of breast cancer patients experienced cancer-related fatigue.
- CRF was significantly associated with low intakes of several nutrients.
- Patients with CRF had decreased gut microbiota diversity.
Takeaway
Breast cancer patients who eat poorly may feel more tired, and this could be connected to the bacteria in their gut.
Methodology
The study evaluated dietary intake and cancer-related fatigue in 342 breast cancer patients, collecting fecal and plasma samples for analysis.
Potential Biases
Recall bias may affect the accuracy of dietary intake data.
Limitations
The study's cross-sectional design limits causal inferences, and dietary intake was assessed via recall, which may introduce bias.
Participant Demographics
Participants were female breast cancer patients aged 18 and older, hospitalized for postoperative chemotherapy.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI −0.0051, −0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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