WFDC2: A Protein in Lung and Oral Cavity Immunity and Cancer
Author Information
Author(s): Lynne Bingle, Simon S Cross, Alec S High, William A Wallace, Doris Rassl, Guanglu Yuan, Ingegerd Hellstrom, Michael A Campos, Colin D Bingle
Primary Institution: University of Sheffield
Hypothesis
Is WFDC2 involved in the innate immune defenses of the lung and oral cavity and associated with lung adenocarcinomas?
Conclusion
WFDC2 may play a role in the innate immune defenses of the lung and oral cavity and is associated with various types of lung cancer.
Supporting Evidence
- WFDC2 is expressed in epithelial cells of the upper airways and in mucous cells of salivary glands.
- Increased WFDC2 expression is observed in patients with Cystic Fibrosis.
- The majority of adenocarcinomas stain positively for WFDC2.
Takeaway
WFDC2 is a protein found in the lungs and mouth that helps protect against infections and may be linked to certain types of lung cancer.
Methodology
Immunohistochemistry and molecular analysis were used to study WFDC2 expression in various tissues and lung cancer samples.
Limitations
The study did not establish a clear association between WFDC2 expression and tumor grade.
Digital Object Identifier (DOI)
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