Breast Cancer Subtypes and Their Impact on Survival in Chinese Women
Author Information
Author(s): Su Yinghao, Zheng Ying, Zheng Wei, Gu Kai, Chen Zhi, Li Guoliang, Cai Qiuyin, Lu Wei, Shu Xiao Ou
Primary Institution: Vanderbilt University Medical Center
Hypothesis
The distribution of molecular subtypes of breast cancer and their prognostic value in Chinese women has not been well documented.
Conclusion
Triple-negative and HER2 subtypes are associated with poorer outcomes compared to the luminal A subtype among Chinese women.
Supporting Evidence
- The prevalence of luminal A, luminal B, HER2, and triple-negative subtypes were 48.6%, 16.7%, 13.7%, and 12.9%, respectively.
- Women with triple-negative breast cancer had a higher frequency of family history of breast cancer than women with other subtypes.
- The 5-year overall survival rates for luminal A, luminal B, HER2, and triple-negative subtypes were 92.9%, 88.6%, 83.2%, and 80.7%, respectively.
Takeaway
This study looked at different types of breast cancer in Chinese women and found that some types are linked to worse health outcomes than others.
Methodology
A population-based cohort study evaluated 2,791 breast cancer patients for molecular subtypes using immunohistochemical assays and followed them for an average of 53.4 months.
Potential Biases
Potential misclassification due to varying criteria for defining ER and PR positivity.
Limitations
ERĪ± and PR status for most participants were obtained from medical charts, and approximately 8% of cases with borderline HER2 positivity were not evaluated with FISH.
Participant Demographics
Women aged 20 to 75 years diagnosed with primary breast cancer in Shanghai, China.
Statistical Information
Confidence Interval
95% CI, 1.09-4.48
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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