Identifying Vaccine Candidates for Anaplasma marginale
Author Information
Author(s): Michael J. Dark, Basima Al-Khedery, Anthony F. Barbet
Primary Institution: University of Florida
Hypothesis
Can high throughput genome sequencing identify conserved candidate vaccine antigens for Anaplasma marginale?
Conclusion
The study identified 19 conserved candidate vaccine antigens that may be suitable for a multi-component recombinant vaccine against Anaplasma marginale.
Supporting Evidence
- High throughput genome sequencing was used to define conservation of different superfamily members in ten U.S. strains of A. marginale.
- The study defined a catalog of 19 conserved candidate vaccine antigens.
- Significantly increased numbers of SNPs were found in A. marginale subspecies centrale compared to U.S. strains.
Takeaway
Scientists looked at different strains of a germ that makes cows sick and found some parts that could help make a better vaccine.
Methodology
High throughput genome sequencing was used to analyze ten U.S. strains of Anaplasma marginale and identify conserved proteins.
Limitations
The study did not include a comprehensive analysis of all possible strains and variations of Anaplasma marginale.
Participant Demographics
The strains analyzed were from various U.S. locations including Florida, Virginia, and Idaho.
Digital Object Identifier (DOI)
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