Carbonic Anhydrase IX in Oligodendroglial Brain Tumors
Author Information
Author(s): Sally Järvelä, Seppo Parkkila, Helena Bragge, Marketta Kähkönen, Anna-Kaisa Parkkila, Ylermi Soini, Silvia Pastorekova, Jaromir Pastorek
Primary Institution: Tampere University Hospital
Hypothesis
This study investigates the role of carbonic anhydrase IX (CA IX) in oligodendroglial brain tumors.
Conclusion
CA IX is an independent prognostic indicator in oligodendroglial brain tumors and correlates inversely with cell proliferation.
Supporting Evidence
- 80% of the tumors showed CA IX expression.
- Tumors with moderate or strong CA IX expression had lower cell proliferation.
- CA IX expression was significantly higher in tumors positive for manganese superoxide dismutase.
Takeaway
The study found that a protein called CA IX is present in many brain tumors and can help predict how well patients will do.
Methodology
The study analyzed tumor samples from 86 patients using immunohistochemistry to assess CA IX expression and correlated it with clinical outcomes.
Participant Demographics
Patients included 71 with primary tumors and 15 with recurrent tumors, median age 40 years.
Statistical Information
P-Value
0.015
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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