Antiviral Properties of Recombinant Porcine SP-D against Influenza A Viruses
Author Information
Author(s): Hillaire Marine L. B., van Eijk Martin, van Trierum Stella E., van Riel Debby, Saelens Xavier, Romijn Roland A., Hemrika Wieger, Fouchier Ron A. M., Kuiken Thijs, Osterhaus Albert D. M. E., Haagsman Henk P., Rimmelzwaan Guus F.
Primary Institution: Erasmus Medical Centre, Rotterdam, The Netherlands
Hypothesis
Recombinant porcine SP-D will be effective against various influenza A viruses in vitro.
Conclusion
Recombinant porcine SP-D shows promise as a novel antiviral agent against influenza A viruses.
Supporting Evidence
- Recombinant porcine SP-D was found to be more potent than recombinant human SP-D.
- Porcine SP-D neutralized a variety of H1N1 and H3N2 influenza A viruses.
- Recombinant porcine SP-D prevented attachment of influenza viruses to epithelial cells in tissue sections.
Takeaway
Scientists tested a special protein from pigs to see if it could help fight the flu, and it worked really well against many types of the virus.
Methodology
The study involved testing the antiviral activity of recombinant porcine SP-D against 30 influenza A viruses using hemagglutination inhibition assays and infection reduction assays.
Potential Biases
Potential conflicts of interest due to employment of some authors by companies involved in the study.
Limitations
The study was conducted in vitro, and further in vivo studies are needed to confirm the efficacy of recombinant porcine SP-D.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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