Pathophysiological Roles of PPARγ in Gastrointestinal Epithelial Cells
2008
Roles of PPARγ in Gut Health and Disease
publication
Evidence: moderate
Author Information
Author(s): Brian M. Necela, E. Aubrey Thompson
Primary Institution: Mayo Clinic Comprehensive Cancer Center
Hypothesis
What is the physiological role of PPARγ in gastrointestinal epithelial cells?
Conclusion
PPARγ plays a significant role in regulating metabolism and inflammation in gastrointestinal epithelial cells.
Supporting Evidence
- PPARγ is highly expressed in gastrointestinal epithelial cells, suggesting an important physiological role.
- Activation of PPARγ in intestinal epithelial cells promotes motility and reduces cellular adhesion.
- Genomic studies indicate that PPARγ regulates metabolism and inflammation in gut epithelial cells.
Takeaway
PPARγ is a protein that helps control how cells in the gut work, especially in keeping them healthy and fighting inflammation.
Methodology
The review summarizes historical and recent data on PPARγ's roles in gut physiology and pathology.
Limitations
The lack of good cellular models to study PPARγ in nontransformed gut epithelial cells limits understanding.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website