Curcumin's Effects on Morphine Tolerance in Mice
Author Information
Author(s): Lin Jui-An, Chen Jenn-Han, Lee Yuan-Wen, Lin Chao-Shun, Hsieh Ming-Hui, Chang Chuen-Chau, Wong Chih-Shung, Chen Judy Ju-Yi, Yeh Geng-Chang, Lin Feng-Yen, Chen Ta-Liang
Primary Institution: Taipei Medical University
Hypothesis
The study aims to evaluate the effect of curcumin on morphine tolerance and the corresponding cytokine/chemokine changes.
Conclusion
Curcumin has a biphasic effect on morphine tolerance, where low doses can attenuate tolerance while high doses may worsen it.
Supporting Evidence
- Low-dose curcumin reduced morphine tolerance in mice.
- High-dose curcumin worsened morphine tolerance.
- 14 cytokines showed significant changes after treatment.
- Curcumin's effects on morphine tolerance are biphasic.
Takeaway
Curcumin can help with pain relief from morphine, but too much can make things worse.
Methodology
Male ICR mice were made tolerant to morphine and treated with low or high doses of curcumin to assess its effects on morphine-induced pain relief and tolerance.
Limitations
The study's findings may not be directly applicable to humans, and the exact mechanisms of curcumin's effects require further investigation.
Participant Demographics
Male ICR mice, weight range 18−22 g.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI for AD50 values ranged from 7.63 to 122 mg/kg.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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