Circadian Disruption Affects Fetal Development in Mice
Author Information
Author(s): Britz Samantha M., Nelson Shay MS, Earhart Kylie M. MS, Pru James K. PhD, Schmitt Emily E. PhD
Primary Institution: University of Wyoming
Hypothesis
How does circadian disruption during pregnancy affect fetal development in mice?
Conclusion
Circadian disruption in pregnant mice leads to significant changes in placental and stomach development.
Supporting Evidence
- Circadian disruption led to significant differences in placental length, thickness, and stomach diameter.
- Measurements were taken using high-frequency ultrasound to ensure accuracy.
- Control and disrupted groups were compared to assess the impact of circadian disruption.
Takeaway
When pregnant mice have their day and night cycles messed up, it can make their babies' tummies and placentas grow differently.
Methodology
Pregnant mice were subjected to a circadian disruption protocol and compared to controls using high-frequency ultrasound to measure fetal development.
Limitations
The study only assessed anatomical structures and did not evaluate long-term effects on offspring.
Participant Demographics
C57BL/6 J female mice, aged four weeks.
Statistical Information
P-Value
0.00016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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