Cytotoxic Effects of Physalis minima on Lung Cancer Cells
Author Information
Author(s): Ooi Kheng Leong, Muhammad Tengku Sifzizul Tengku, Sulaiman Shaida Fariza
Primary Institution: Universiti Sains Malaysia
Hypothesis
The chloroform extract of Physalis minima induces apoptosis in NCI-H23 lung adenocarcinoma cells.
Conclusion
The chloroform extract of Physalis minima significantly inhibits the growth of NCI-H23 cells and induces apoptosis through specific molecular pathways.
Supporting Evidence
- The chloroform extract showed over 75% growth inhibition in NCI-H23 cells.
- Apoptotic characteristics were confirmed through DNA fragmentation and morphological analysis.
- Gene expression analysis indicated significant upregulation of c-myc, caspase-3, and p53.
Takeaway
This study found that a plant extract can help kill cancer cells by making them self-destruct.
Methodology
The study used various assays to evaluate cytotoxicity, DNA fragmentation, and gene expression in treated NCI-H23 cells.
Limitations
The study primarily focused on in vitro results, which may not fully represent in vivo effects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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