LnCeCell 2.0: an updated resource for lncRNA-associated ceRNA networks and web tools based on single-cell and spatial transcriptomics sequencing data
2025
LnCeCell 2.0: Updated Resource for lncRNA-associated ceRNA Networks
Sample size: 1002988
publication
Evidence: high
Author Information
Author(s): Guo Qiuyan, Liu Qian, He Danni, Xin Mengyu, Dai Yifan, Sun Rui, Li Houxing, Zhang Yujie, Li Jiatong, Kong Congcong, Gao Yue, Zhi Hui, Li Feng, Ning Shangwei, Wang Peng
Primary Institution: Harbin Medical University
Conclusion
LnCeCell 2.0 provides an extensive database of lncRNA-associated ceRNA networks with improved features and expanded datasets.
Supporting Evidence
- LnCeCell 2.0 includes 257 single-cell RNA sequencing datasets across 86 diseases.
- 836,581 cell-specific ceRNA interactions were identified for 1,002,988 cells.
- 15,489 experimentally supported lncRNA biomarkers related to disease were curated.
Takeaway
LnCeCell 2.0 is like a big library that helps scientists understand how certain RNA molecules work together in our cells, especially in diseases like cancer.
Methodology
The database was updated with new datasets from single-cell RNA sequencing and spatial transcriptomics, along with manual curation of lncRNA biomarkers.
Digital Object Identifier (DOI)
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