Tissue Oxygen Saturation and Mortality in Sepsis Patients
Author Information
Author(s): Vorwerk C, Coats T
Primary Institution: University Hospitals of Leicester, UK
Hypothesis
The study aims to assess the relationship between tissue oxygen saturation and in-hospital mortality for ED patients with severe sepsis or septic shock.
Conclusion
A consistently low tissue oxygen saturation despite initial sepsis resuscitation is linked to higher in-hospital mortality.
Supporting Evidence
- 24 out of 49 patients (49%) died during the study.
- Nonsurvivors were significantly older than survivors.
- StO2 improved significantly in survivors but remained low in nonsurvivors.
- StO2 was a better prognostic indicator than conventional vital signs.
Takeaway
If a patient with sepsis has low oxygen levels in their tissues, they are more likely to not survive, even after treatment.
Methodology
Prospective cohort study of adult ED patients with severe sepsis or septic shock, monitoring vital signs and StO2 measurements.
Participant Demographics
Adult patients with severe sepsis or septic shock, with a mean age of 79 for nonsurvivors and 64 for survivors.
Statistical Information
P-Value
0.008, 0.97, 0.006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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