Effectiveness of Artesunate-Mefloquine for Malaria in Nigeria
Author Information
Author(s): Agomo Philip U, Meremikwu Martin M, Watila Ismaila M, Omalu Innocent J, Odey Friday A, Oguche Stephen, Ezeiru Valentine I, Aina Olugbenga O
Primary Institution: Nigerian Institute of Medical Research
Hypothesis
The combination of artesunate and mefloquine is effective, safe, and well-tolerated for treating uncomplicated malaria in Nigeria.
Conclusion
The co-packaged formulation of artesunate and mefloquine is highly efficacious, safe, and well-tolerated for treating uncomplicated P. falciparum malaria in Nigeria.
Supporting Evidence
- Cure rates were over 90% at day 28 for both treatment groups.
- Mean parasite clearance times were 40.1 hours for group I and 42.4 hours for group II.
- No serious adverse events were reported during the study.
Takeaway
This study tested a new malaria treatment and found it works really well and is safe for kids and adults in Nigeria.
Methodology
A multi-centre, open-label trial with a three-day regimen of artesunate and mefloquine, following WHO protocols.
Potential Biases
Potential bias due to lack of blinding and the open-label design.
Limitations
The study did not perform PCR analysis to confirm recrudescence or new infections.
Participant Demographics
Participants included children and adults, with weights ranging from 15 kg to over 30 kg.
Statistical Information
Statistical Significance
p > 0.05
Digital Object Identifier (DOI)
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