Toxicity in Prostate Cancer Patients Treated with Radiation Therapy
Author Information
Author(s): Ghadjar Pirus, Vock Jacqueline, Vetterli Daniel, Manser Peter, Bigler Roland, Tille Jan, Madlung Axel, Behrensmeier Frank, Mini Roberto, Aebersold Daniel M
Primary Institution: Department of Radiation Oncology with Division of Medical Radiation Physics, University of Bern, Inselspital, Bern, Switzerland
Hypothesis
To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking.
Conclusion
GI toxicity rates after dose escalated IMRT and organ tracking are excellent, while GU toxicity rates are comparable to other studies when considering pre-treatment morbidity.
Supporting Evidence
- Acute grade 2 GI toxicity was 3% and maximal late grade 2 GI toxicity was 8%.
- No grade 3 GI toxicity occurred.
- Acute grade 2 GU toxicity occurred in 56% of patients.
- Late grade 2 GU toxicity decreased to 15% at the end of follow-up.
Takeaway
Doctors treated 39 men with prostate cancer using a special type of radiation therapy, and they found that the side effects were mostly mild and got better over time.
Methodology
Patients were treated with 80 Gy IMRT along with organ tracking, and toxicity was scored according to the CTC scale version 3.0.
Potential Biases
The study may have biases due to its retrospective design and the exclusion of patients with certain conditions.
Limitations
The study had a relatively small number of patients and was retrospective in nature.
Participant Demographics
All patients were Caucasian men with a median age of 69 years.
Statistical Information
P-Value
P < .001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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