Neutrophil-to-HDL Ratio and Heart Disease Risk
Author Information
Author(s): Wu Chia-Chen, Wu Chia-Hui, Lee Chien-Ho, Chen Tien-Yu, Cheng Cheng-I
Primary Institution: Kaohsiung Chang Gung Memorial Hospital
Hypothesis
What is the prognostic value of hematologic ratios in patients with ischemic heart disease?
Conclusion
The study found that a high neutrophil-to-HDL ratio is associated with an increased risk of all-cause mortality in patients with ischemic heart disease.
Supporting Evidence
- Patients in the highest quartile of the neutrophil/HDL ratio had a 41% increased risk of all-cause mortality.
- The study included 2265 patients with a median follow-up of 80 months.
- Other hematologic ratios did not show significant associations with mortality.
- The neutrophil/HDL ratio was the only significant predictor of mortality among the ratios studied.
Takeaway
Doctors can use the neutrophil-to-HDL ratio to help figure out how likely someone with heart disease is to have serious health problems.
Methodology
The study analyzed data from NHANES, tracking mortality in patients with ischemic heart disease and examining the associations between hematologic ratios and all-cause mortality using Cox regression.
Potential Biases
Potential recall bias due to reliance on self-reported medical history.
Limitations
The study lacked direct diagnostic confirmation of ischemic heart disease and relied on participant-reported data, which may introduce recall bias.
Participant Demographics
Community-dwelling adults aged 20 and older with established ischemic heart disease.
Statistical Information
P-Value
p<0.001 for neutrophil/HDL ratio
Confidence Interval
95% CI: 1.13–1.77 for highest quartile of neutrophil/HDL ratio
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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