MYC/MAX/MAD Network in Oesophageal Adenocarcinoma
Author Information
Author(s): Boult J K R, Tanière P, Hallissey M T, Campbell M J, Tselepis C
Primary Institution: CRUK Institute for Cancer Studies, University of Birmingham
Hypothesis
MAD expression would be repressed in the progression of oesophageal adenocarcinoma in a reciprocal pattern to c-MYC.
Conclusion
The expression patterns of c-MYC, MAX, and the MAD family were shown to be deregulated in the oesophageal cancer model.
Supporting Evidence
- Oesophageal adenocarcinoma has increased more rapidly than any other cancer in the Western world.
- Median survival time for patients with oesophageal adenocarcinoma is merely 18 months post-diagnosis.
- Elevated expression of c-MYC has been demonstrated in oesophageal adenocarcinoma.
Takeaway
This study looked at how certain proteins behave in a type of esophageal cancer and found that some are not working as they should.
Methodology
mRNA expression was examined by qRT–PCR, and protein levels were assessed using immunohistochemistry and western blotting.
Potential Biases
Potential bias in sample selection and interpretation of immunohistochemical results.
Limitations
The study may not account for all isoforms of the proteins involved.
Participant Demographics
Patients with oesophageal adenocarcinoma and Barrett's metaplasia.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website