L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury

2024

Triglyceride-Glucose Body Mass Index and Mortality in ICU Patients with Sepsis-Associated Acute Kidney Injury

Sample size: 3349 publication 10 minutes Evidence: high

Author Information

Author(s): Xu Heping, Mo Ruiyong, Liu Yiqiao, Niu Huan, Cai Xiongwei, He Ping

Primary Institution: Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China

Hypothesis

The study investigates the association between triglyceride-glucose body mass index (TyG-BMI) and short-term mortality in ICU patients with sepsis-associated acute kidney injury.

Conclusion

Higher TyG-BMI values are significantly associated with reduced short-term mortality rates in ICU patients with sepsis-associated acute kidney injury.

Supporting Evidence

Higher TyG-BMI values were significantly associated with reduced short-term mortality rates.
For each standard deviation increase in TyG-BMI, the risk of all-cause death decreased by 0.2%.
Kaplan–Meier analysis showed that patients with high TyG-BMIs had significantly lower mortality rates than those with low TyG-BMIs.
The study included 3,349 patients, with males accounting for 60.5% of the patients.

Takeaway

This study found that patients with higher triglyceride-glucose body mass index (TyG-BMI) are less likely to die in the short term if they have sepsis-related kidney problems.

Methodology

A retrospective analysis using data from the MIMIC-IV database, employing multivariate Cox proportional hazards regression and Kaplan–Meier survival analysis.