Collagenase Promotes the Cellular Responses to Injury and Wound Healing In Vivo
2005
Collagenase and Wound Healing
Sample size: 8
publication
Evidence: high
Author Information
Author(s): Riley Kathleen N., Herman Ira M.
Primary Institution: Department of Physiology, Tufts University School of Medicine
Hypothesis
Does Clostridial collagenase enhance keratinocyte responses to injury and promote wound healing?
Conclusion
Clostridial collagenase stimulates keratinocyte responses to injury and may be a novel treatment for wound healing.
Supporting Evidence
- Collagenase treatment resulted in a 2-fold increase in keratinocyte proliferation and migration in vitro.
- Collagenase was superior to other treatments in promoting wound healing in vivo.
- Statistically significant differences in wound healing were observed starting from Day 6 of the trial.
Takeaway
Collagenase helps skin cells heal wounds faster, making it a good option for treating injuries.
Methodology
The study involved in vitro tests on keratinocytes and an in vivo double-blind study on Yucatan Micropigs with various treatments.
Participant Demographics
Healthy female adult Micro-Yucatan Miniature swine
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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