Manganese superoxide dismutase as a diagnostic marker for mesothelioma
Author Information
Author(s): Kahlos K, Pääkkö P, Kurttila E, Soini Y, Kinnula V L
Primary Institution: University of Oulu and Oulu University Hospital
Hypothesis
Can manganese superoxide dismutase (MnSOD) be used in the differential diagnosis of malignant mesothelioma and metastatic adenocarcinoma of the pleura?
Conclusion
MnSOD immunoreactivity can help differentiate between malignant mesothelioma and metastatic adenocarcinoma of the pleura.
Supporting Evidence
- MnSOD expression was high in mesothelioma compared to healthy pleural mesothelium.
- Fifteen of the 35 malignant mesotheliomas showed moderate or strong MnSOD expression without microwave pretreatment.
- Twenty-three of the 35 malignant mesotheliomas showed moderate or strong MnSOD expression with microwave pretreatment.
- Only mesothelioma biopsies showed strong MnSOD reactivity.
- One-third of the adenocarcinomas showed no MnSOD reactivity.
Takeaway
This study found that a specific protein called MnSOD is much more active in mesothelioma than in another type of lung cancer, which can help doctors tell them apart.
Methodology
MnSOD expression was assessed using immunohistochemistry in biopsies of malignant mesothelioma (n = 35) and metastatic adenocarcinoma of the pleura (n = 21).
Statistical Information
P-Value
P = 0.002 and P< 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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