Hepatotoxicity from Horse ATG and Recovery with Rabbit ATG: A Case Report
Author Information
Author(s): Khalid A Al-Anazi, Mahmoud D Aljurf, Fahad Z Al-Sharif, Hamad M Al-Omar, Ahmed Alami, Fayyaz Farooq
Primary Institution: King Faisal Specialist Hospital and Research Centre
Hypothesis
Can switching from horse antithymocyte globulin (ATG) to rabbit ATG reverse hepatotoxicity in patients undergoing hematopoietic stem cell transplantation?
Conclusion
The hepatotoxicity associated with antithymocyte globulin can vary in severity and may be reversible by switching to a different type of ATG.
Supporting Evidence
- The patient developed severe hepatotoxicity after receiving horse ATG.
- Switching to rabbit ATG led to improvement in liver function tests.
- The patient successfully underwent her planned allogeneic hematopoietic stem cell transplant.
Takeaway
A young girl got sick from a medicine called horse ATG, but when doctors switched her to rabbit ATG, she got better and was able to have her transplant.
Methodology
The patient received horse ATG followed by rabbit ATG as part of her conditioning regimen for hematopoietic stem cell transplantation.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
A 23-year-old Saudi female with Fanconi anemia.
Digital Object Identifier (DOI)
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