Vascular Patterns in Lymphomas
Author Information
Author(s): Passalidou E, Stewart M, Trivella M, Steers G, Pillai G, Dogan A, Leigh I, Hatton C, Harris A, Gatter K, Pezzella F
Primary Institution: Cancer Research UK
Hypothesis
Is high microvessel density associated with more aggressive lymphomas?
Conclusion
The study found that microvessel density is higher in the paracortex than in the follicles of both reactive lymph nodes and lymph nodes with follicular lymphomas.
Supporting Evidence
- Microvessel density was lower in the follicles than in the paracortex.
- There was no difference in microvessel density between reactive germinal centers and neoplastic follicles.
- Diffuse large cell lymphomas had higher microvessel density than neoplastic and reactive follicles.
Takeaway
This study looked at blood vessel patterns in lymphomas and found that the area around the lymph nodes has more blood vessels than the lymph nodes themselves.
Methodology
The study assessed microvessel density and vascular phenotype in tissue samples from patients with follicular non-Hodgkin's lymphoma, large B-cell non-Hodgkin's lymphoma, and reactive hyperplasia.
Limitations
The study had a small number of cases for some comparisons, particularly in areas of diffuse transformation.
Participant Demographics
Patients included 23 with follicular non-Hodgkin's lymphoma, 21 with large B-cell non-Hodgkin's lymphoma, and 17 with reactive hyperplasia.
Statistical Information
P-Value
<0.0009
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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