Ki-67 Expression in Oral Lichen Planus: A Systematic Review
Author Information
Author(s): Bahramian Aila DDS, MSc, Motahari Paria DDS, MSc, Hanifenezhad Alireza DDS
Primary Institution: Tabriz University of Medical Sciences
Hypothesis
Is there any variation in the expression of the Ki-67 marker in biopsied samples from OLP without dysplasia with OED?
Conclusion
The study found that Ki-67 expression is significantly lower in oral lichen planus without dysplasia compared to oral epithelial dysplasia.
Supporting Evidence
- The meta-analysis included 12 studies with a total of 593 patients.
- Ki-67 expression was significantly lower in OLP without dysplasia compared to OED.
- The study followed PRISMA guidelines for systematic reviews.
- Quality assessment showed that none of the studies were of low quality.
- Statistical analysis indicated no significant heterogeneity among studies.
- Results suggest Ki-67 could be a useful marker for distinguishing between OLP and OED.
Takeaway
This study looked at how a marker called Ki-67 behaves in a mouth condition called oral lichen planus compared to a more serious condition. It found that Ki-67 is lower in the less serious condition.
Methodology
The study systematically reviewed and analyzed articles on Ki-67 expression in oral lichen planus and oral epithelial dysplasia using Comprehensive Meta-Analysis software.
Potential Biases
The quality of studies was assessed using the Newcastle-Ottawa scale, with most studies having relatively good quality.
Limitations
The study included only retrospective articles and may not represent all cases of oral lichen planus.
Participant Demographics
The studies included both men and women, primarily aged above 35 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
0.18–0.47
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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